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Gene prediction: compare and CONTRAST

Paul Flicek

Author Affiliations

European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

Genome Biology 2007, 8:233  doi:10.1186/gb-2007-8-12-233

Published: 20 December 2007


CONTRAST, a new gene-prediction algorithm that uses sophisticated machine-learning techniques, has pushed de novo prediction accuracy to new heights, and has significantly closed the gap between de novo and evidence-based methods for human genome annotation.