Proportions of phosphoproteins with orthologs. To examine the conservation of phosphoproteins in comparison to the entire human proteome, we aligned two-directionally against the protein sequences of Saccharomyces cerevisiae, D. melanogaster, D. rerio, Gallus gallus, Bos bovis, Rattus norvegicus and Mus musculus via BLASTP. Phosphoproteins (red) have a much higher likelihood to have an ortholog than the entire set of human proteins from SwissProt (blue).
Gnad et al. Genome Biology 2007 8:R250 doi:10.1186/gb-2007-8-11-r250