CNS transcriptomes respond to caloric restriction in a region- and age-dependent manner. (a) CNS gene expression responses to CR. (b) Metabolic and signaling pathways in which genes were significantly affected by CR in all five CNS regions. Red, upregulated; blue, downregulated. (c) CNS AAGs reverted by CR. The percentage of AAGs reverted by CR is shown at the top of each bar. Note that the spinal cord exhibits a much larger percentage of upregulated AAGs that are reverted by CR compared to the other CNS regions. Gene lists are in Table S4a,c in Additional data file 1.
Xu et al. Genome Biology 2007 8:R234 doi:10.1186/gb-2007-8-11-r234