Additional data file 10.

Each page of the PDF contains a plot of the log2 ratios for clones (censored at ±0.3) on the long arm of chromosome 7 for five samples analyzed in [15] (samples S20, S30, S32, S40 and S60). The fitted loess curve for this genomic region has been overlaid in blue and the thresholds used in [15] to identify clones harboring CNVs are shown by horizontal dashed gray lines. On all five plots we can observe that the fitted loess curve has a trough at around 75 and 100 Mb (this is common to all samples - see Additional data file 6), suggesting that this is a technical artifact. Moreover, in all five plots a small number of clones in these regions have log2 ratios that are lower than the threshold and, consequently, they are flagged (almost certainly incorrectly) as harboring a CNV.

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Marioni et al. Genome Biology 2007 8:R228   doi:10.1186/gb-2007-8-10-r228