Additional data file 4.
Between-sample normalization. A. Shown are data normalized based on spike-in controls for the same miRNAs and factors as in Figure 3 in the main text. B. miRNAs and factors with at least one association at adjusted p < 0.01 based on data normalized using spike-in controls. All miRNAs thus identified were also identified after sample median centering with the exception of miR-152, which was found to be associated with all three factors at p < 0.05 (Additional data file 18). Heatmap colours reflect relative miRNA expression. The expression values for a given sample group of interest were summarized by their mean. Brackets in the left margin indicate members of the same miRNA family. Significance levels are indicated in the right margins: * adjusted p < 0.05, ** adjusted p < 0.01, *** adjusted p < 0.001. Abbreviations for subtype: B = Basal-like, H = HER2+, LA = Luminal A, LB = Luminal B, N = Normal-like.
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Blenkiron et al. Genome Biology 2007 8:R214 doi:10.1186/gb-2007-8-10-r214