HMM for predicting isochore boundaries. States are shown as large circles, with transitions indicated by directed arrows. Transition probabilities are omitted for clarity. Within each outer state is a GHMM profile. States represent isochores, or discrete ranges of G+C density: I = (0,43%), II = (43-51%), III = (51-57%), and IV = (57-100%).
Allen et al. Genome Biology 2006 7(Suppl 1):S9 doi:10.1186/gb-2006-7-s1-s9