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The subcellular localization of the mammalian proteome comes a fraction closer

Jeremy C Simpson* and Rainer Pepperkok

Author Affiliations

Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

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Genome Biology 2006, 7:222  doi:10.1186/gb-2006-7-6-222

Published: 23 June 2006


Another step along the road towards determining the subcellular localization of a complete mammalian proteome has been taken with a study using cellular fractionation and protein correlation profiling to identify and localize organellar proteins. Here we discuss this new work in the context of other strategies for large-scale subcellular localization.