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Histone H4 lysine 16 acetylation breaks the genome's silence

Wei-Jong Shia12, Samantha G Pattenden1 and Jerry L Workman1*

Author Affiliations

1 Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA

2 Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA

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Genome Biology 2006, 7:217  doi:10.1186/gb-2006-7-5-217

Published: 10 May 2006


Acetylation at histone H4 lysine 16 is involved in many cellular processes in organisms as diverse as yeast and humans. A recent biochemical study pinpoints this particular acetylation mark as a switch for changing chromatin from a repressive to a transcriptionally active state.