The regulatory interactions between two Arabidopsis CNL proteins, RPM1 and RPS2, RPM1-Interacting Protein 4 (RIN4) and three pathogen virulence effectors, AvrB, AvrRpm1 and AvrRpt2 [51-55]. The protein RPM1 detects the phosphorylation of RIN4 by AvrB and AvrRpm1 and elicits the resistance response. This outcome can be blocked by AvrRpt2, a protease that cleaves RIN4. The disappearance of RIN4 is detected by RPS2, resulting in elicitation of the defense response.
McHale et al. Genome Biology 2006 7:212 doi:10.1186/gb-2006-7-4-212