bcd, gd, and Tl regulate nuclear density patterns along both major body axes. Cylindrical projections of nuclear density patterns in (a) wild-type, (b) bcd12 mutant, (c) gd7 mutant, and (d) Tl10B mutant embryos. To reduce noise, information from the left and right sides of each embryo was averaged. All embryos were from stages 5:25-100%. Axes and isodensity contours are as described in Figure 1. All three mutants exhibit changes in the pattern of density along both body axes. Note that while it appears that the total number of nuclei in Tl10B mutants is less than in the wild-type embryos, this reflects a difference between fly strains and not an effect of the Tl gene as there is no statistically significant difference between the average number of nuclei in Tl10B mutants versus their wild-type-like siblings, which are derived from Tl10B hetrozygous mothers.
Keränen et al. Genome Biology 2006 7:R124 doi:10.1186/gb-2006-7-12-r124