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How complete are current yeast and human protein-interaction networks?

G Traver Hart1, Arun K Ramani12 and Edward M Marcotte1*

Author Affiliations

1 Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA

2 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK

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Genome Biology 2006, 7:120  doi:10.1186/gb-2006-7-11-120

Published: 1 December 2006


We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions.