Additional data file 6.

The mean D-index and associated standard errors over the ten hybrid prognostic classifiers (HPIp) in the three external independent cohorts. The D-index of the HPIp is parameterized by the weight wM given to MPIp. Thus, for wM = 0 we have a pure histopathological classifier, while for wM = 1 the prognostic index HPIp = MPIp. It turns out that, because of the relatively small number of samples (36) with available node status and NPI information in JRH-2, there were weight values for which the D-index became too large for graphical representation.

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Teschendorff et al. Genome Biology 2006 7:R101   doi:10.1186/gb-2006-7-10-r101