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Leaner and meaner genomes in Escherichia coli

David W Ussery

Author Affiliations

Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark

Genome Biology 2006, 7:237  doi:10.1186/gb-2006-7-10-237

Published: 24 October 2006


A 'better' Escherichia coli K-12 genome has recently been engineered in which about 15% of the genome has been removed by planned deletions. Comparison with related bacterial genomes that have undergone a natural reduction in size suggests that there is plenty of scope for yet more deletions.