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Canonical Wnt signaling: high-throughput RNAi widens the path

Anthony MC Brown

Author Affiliations

Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Prevention Center, New York, NY 10021, USA

Genome Biology 2005, 6:231  doi:10.1186/gb-2005-6-9-231

Published: 31 August 2005


The canonical Wnt signaling pathway is highly conserved in evolution, widely used throughout animal development, and frequently hyperactive in cancer. Although Wnt signaling has been the subject of extensive genetic analysis in the past, some 200 genes have now been identified as candidate modulators of this pathway by a recent study using high-throughput RNAi screening.