Connecting the dots in Huntington's disease with protein interaction networks
1 Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
2 The Center for Neurogenetics and Neurotherapeutics, University of Washington, Seattle, WA 98195, USA
Genome Biology 2005, 6:210 doi:10.1186/gb-2005-6-3-210Published: 28 February 2005
Analysis of protein-protein interaction networks is becoming important for inferring the function of uncharacterized proteins. A recent study using this approach has identified new proteins and interactions that might be involved in the pathogenesis of the neurodegenerative disorder Huntington's disease, including a GTPase-activating protein that co-localizes with protein aggregates in Huntington's disease patients.