Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Open Badges Minireview

Connecting the dots in Huntington's disease with protein interaction networks

Flaviano Giorgini1 and Paul J Muchowski12*

Author Affiliations

1 Department of Pharmacology, University of Washington, Seattle, WA 98195, USA

2 The Center for Neurogenetics and Neurotherapeutics, University of Washington, Seattle, WA 98195, USA

For all author emails, please log on.

Genome Biology 2005, 6:210  doi:10.1186/gb-2005-6-3-210

Published: 28 February 2005


Analysis of protein-protein interaction networks is becoming important for inferring the function of uncharacterized proteins. A recent study using this approach has identified new proteins and interactions that might be involved in the pathogenesis of the neurodegenerative disorder Huntington's disease, including a GTPase-activating protein that co-localizes with protein aggregates in Huntington's disease patients.