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Temporal and spatial patterning of an organ by a single transcription factor

Diya Banerjee and Frank J Slack*

Author Affiliations

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA

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Genome Biology 2005, 6:205  doi:10.1186/gb-2005-6-2-205

Published: 25 January 2005


During the formation of animal organs, a single regulatory factor can control the majority of cell-fate decisions, but the mechanisms by which this occurs are poorly understood. One such regulator, the nematode transcription factor PHA-4, functions together with various cis-regulatory elements in target genes to regulate spatial and temporal patterning during development of the pharynx.