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The regulation of endocytosis by kinases: cell biology meets genomics

Zita Balklava and Barth D Grant*

Author Affiliations

Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA

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Genome Biology 2005, 6:245  doi:10.1186/gb-2005-6-13-245

Published: 3 January 2006


The mechanisms of signal transduction and vesicular transport have traditionally been studied in isolation, but recent studies make it clear that the two processes are inextricably linked. A new genome-wide analysis of human kinases using RNA interference shows an unexpected depth and complexity to the interactions between these processes.