The regulation of endocytosis by kinases: cell biology meets genomics
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
Genome Biology 2005, 6:245 doi:10.1186/gb-2005-6-13-245Published: 3 January 2006
The mechanisms of signal transduction and vesicular transport have traditionally been studied in isolation, but recent studies make it clear that the two processes are inextricably linked. A new genome-wide analysis of human kinases using RNA interference shows an unexpected depth and complexity to the interactions between these processes.