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Recent developments in membrane-protein structural genomics

Fei Philip Gao* and Timothy A Cross

Author Affiliations

Department of Chemistry and Biochemistry, and the National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA

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Genome Biology 2005, 6:244  doi:10.1186/gb-2005-6-13-244

Published: 3 January 2006


Recent work has identified the topology of almost all the inner membrane proteins in Escherichia coli, and advances in nuclear magnetic resonance spectroscopy now allow the determination of α-helical membrane protein structures at high resolution. Together these developments will help overcome the current limitations of high-throughput determination of membrane protein structures.