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Close encounters between active genes in the nucleus

Chien-Hui Chuang and Andrew S Belmont*

Author Affiliations

Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA

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Genome Biology 2005, 6:237  doi:10.1186/gb-2005-6-11-237

Published: 19 October 2005


A recent paper demonstrates that coregulated genes on different chromosomes show surprisingly high frequencies of colocalization within the nucleus; this complements similar results found previously for genes localized tens of megabases apart on a single chromosome. Colocalization could be related to the earlier observation of active genes associating with foci where RNA polymerase II is concentrated.