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Chemical genomics in yeast

Charles Brenner

Author Affiliations

Departments of Genetics and Biochemistry and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA

Genome Biology 2004, 5:240  doi:10.1186/gb-2004-5-9-240

Published: 27 August 2004


Many drugs have unknown, controversial or multiple mechanisms of action. Four recent 'chemical genomic' studies, using genome-scale collections of yeast gene deletions that were either arrayed or barcoded, have presented complementary approaches to identifying gene-drug and pathway-drug interactions.