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After 'completion': the changing face of human chromosomes 21 and 22

Todd Duane Taylor

Author Affiliations

RIKEN Genomic Sciences Center, Human Genome Research Group, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

Genome Biology 2004, 5:111  doi:10.1186/gb-2004-5-7-111

Published: 30 June 2004


In the four years since the publication of the first two 'complete' human chromosome sequences the type of research being done on each has shifted subtly, reflecting the impact of genomic data on biological science in general. There is now considerably more gene-expression evidence to support predicted genes, and the annotation of functions for previously unknown genes, including those implicated in disease, is gradually improving.