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Prolinks: a database of protein functional linkages derived from coevolution

Peter M Bowers1, Matteo Pellegrini1, Mike J Thompson1, Joe Fierro2, Todd O Yeates1 and David Eisenberg1*

Author Affiliations

1 Institute for Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA

2 454 Corporation, Branford, CT 06405, USA

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Genome Biology 2004, 5:R35  doi:

Published: 16 April 2004


The advent of whole-genome sequencing has led to methods that infer protein function and linkages. We have combined four such algorithms (phylogenetic profile, Rosetta Stone, gene neighbor and gene cluster) in a single database - Prolinks - that spans 83 organisms and includes 10 million high-confidence links. The Proteome Navigator tool allows users to browse predicted linkage networks interactively, providing accompanying annotation from public databases. The Prolinks database and the Proteome Navigator tool are available for use online at webcite.