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The mechanism of prion strain propagation

Glenn C Telling

Author Affiliations

Sanders Brown Center on Aging, Department of Microbiology, Immunology and Molecular Genetics, Department of Neurology, and PhD Program in Gerontology, University of Kentucky, Lexington, KY 40536, USA

Genome Biology 2004, 5:222  doi:

Published: 22 April 2004


Studies of mammalian prion diseases such as bovine spongiform encephalopathy have suggested that different strains consist of prion proteins with different conformations. Two recent studies of yeast prions have now formally demonstrated that multiple stable protein conformations are the basis of strain variation.