Global circadian regulation of transcriptional activities in cyanobacteria. (a-d) Representative traces of various classes of rhythmic waveforms resulting from the promoter-trap experiment described in . Promoter activity is measured as luminescence from a luciferase reporter. Modified from . (e) Overexpression of the KaiC protein causes the activity of some promoters (clock-dominated, or high-amplitude, promoters) to be essentially abolished, while (f) clock-modulated, or low-amplitude, promoters are repressed to a basal level that is significant but non-rhythmic. Modified from .
Johnson Genome Biology 2004 5:217