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Rewiring the transcriptional regulatory circuits of cells

Devin R Scannell and Ken Wolfe*

Author Affiliations

Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin 2, Ireland

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Genome Biology 2004, 5:206  doi:10.1186/gb-2004-5-2-206

Published: 29 January 2004


The molecular mechanisms that regulate gene expression can evolve either by changing the cis-acting DNA elements in promoters, or by replacing the trans-acting regulatory proteins. New data from yeast species show that both processes can happen.