Rewiring the transcriptional regulatory circuits of cells
Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin 2, Ireland
Genome Biology 2004, 5:206 doi:10.1186/gb-2004-5-2-206Published: 29 January 2004
The molecular mechanisms that regulate gene expression can evolve either by changing the cis-acting DNA elements in promoters, or by replacing the trans-acting regulatory proteins. New data from yeast species show that both processes can happen.