Figure 1.

Accuracy of p-value estimations. To examine the accuracy of our p-value estimates, we compared the empirical p-value (computed from the observed distribution of scores) to p-values computed using either the exact method described above (black points) or Gaussian approximation (gray points). The scores represent the simple score at a distance of 0.1 substitutions per site calculated using the Gcn4p matrix from SCPD [33]. Other models and matrices produce similar results.

Moses et al. Genome Biology 2004 5:R98   doi:10.1186/gb-2004-5-12-r98
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