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Genomic and proteomic adaptations to growth at high temperature

Donal A Hickey1* and Gregory AC Singer12

Author Affiliations

1 Department of Biology, Concordia University, 7141 Sherbrooke Street, Montreal, Quebec, H4B 1R6, Canada

2 Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA

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Genome Biology 2004, 5:117  doi:10.1186/gb-2004-5-10-117

Published: 30 September 2004


Most positively selected mutations cause changes in metabolism, resulting in a better-adapted phenotype. But as well as acting on the information content of genes, natural selection may also act directly on nucleic acid and protein molecules. We review the evidence for direct temperature-dependent natural selection acting on genomes, transcriptomes and proteomes.