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The role of DNA sequence in centromere formation

Jonathan C Lamb and James A Birchler*

Author Affiliations

University of Missouri, Division of Biological Sciences, Columbia, MO 65211, USA

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Genome Biology 2003, 4:214  doi:10.1186/gb-2003-4-5-214

Published: 29 April 2003


Centromeres are key to the correct segregation and inheritance of genetic information. Eukaryotic centromeres, which are located in large blocks of highly repetitive DNA, have been notoriously difficult to sequence. Several groups have recently succeeded in analyzing centromeric sequences in human, Drosophila and Arabidopsis, providing new insights into the importance of DNA sequence for centromere function.