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All that antisense

Jonathan B Weitzman

Citation and License

Genome Biology 2003, 4:spotlight-20030319-01  doi:10.1186/gb-spotlight-20030319-01

The electronic version of this article is the complete one and can be found online at:

Published:19 March 2003

© 2003 BioMed Central Ltd

Research news

Only a few examples of antisense transcripts have been extensively characterized in the human genome and they are often associated with imprinted loci. In an Advanced Online Publication in Nature Biotechnology Rodrigo Yelin and colleagues at Compugen Ltd in Israel propose that regulation by antisense transcription may be quite frequent (Nature Biotechnology, 17 March 2003, doi:10.1038/nbt808). They used a computational approach (the 'Antisensor' algorithm) to identify 2,667 human genomic loci with evidence of transcripts from both strands. Microarray analysis with strand-specific oligonucleotide probes demonstrated that as many as 60% of these may be true sense-antisense pairs. This places the number of possible antisense-regulated genes much higher than previous estimates.


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  6. Computational discovery of sense-antisense transcription in the human and mouse genomes.

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