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Extending knowledge of Escherichia coli metabolism by modeling and experiment

Eberhard O Voit1 and Monica Riley2*

Author Affiliations

1 Medical University of South Carolina, Charleston, SC 29425, USA

2 Marine Biological Laboratory, Woods Hole, MA 02543, USA

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Genome Biology 2003, 4:235  doi:10.1186/gb-2003-4-11-235

Published: 28 October 2003


One of the challenges for 'post-genomic' biology is the integration of data from many different sources. Two recent studies independently take steps towards this goal for Escherichia coli, using mathematical modeling and a combination of gene expression and protein levels to predict new gene functions and metabolic behaviors.