Extending knowledge of Escherichia coli metabolism by modeling and experiment
1 Medical University of South Carolina, Charleston, SC 29425, USA
2 Marine Biological Laboratory, Woods Hole, MA 02543, USA
Genome Biology 2003, 4:235 doi:10.1186/gb-2003-4-11-235Published: 28 October 2003
One of the challenges for 'post-genomic' biology is the integration of data from many different sources. Two recent studies independently take steps towards this goal for Escherichia coli, using mathematical modeling and a combination of gene expression and protein levels to predict new gene functions and metabolic behaviors.