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Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae

Oscar M Aparicio

Author Affiliations

Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-1340, USA

Genome Biology 2003, 4:230  doi:10.1186/gb-2003-4-10-230

Published: 24 September 2003


Gene inactivation is the cornerstone of functional genetic analysis, but the analysis of essential genes requires conditional inactivation of the gene product. A new study has adapted a simple method for creating conditional alleles to allow large-scale analysis of essential genes in Saccharomyces cerevisiae and has identified a role in DNA replication for a newly identified protein complex.