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Antibody fingerprint

Jonathan B Weitzman

Genome Biology 2003, 4:spotlight-20030102-01  doi:10.1186/gb-spotlight-20030102-01

The electronic version of this article is the complete one and can be found online at:

Published:2 January 2003

© 2003 BioMed Central Ltd

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In an Advanced Online Publication in Nature Biotechnology, Paul Mintz and colleagues at the University of Texas M.D. Anderson Cancer Center in Texas, describe the use of phage-display technology to examine the repertoire of circulating, anti-tumour antibodies in the blood of prostate cancer patients (Nature Biotechnology, 23 December 2002, DOI:10.1038/nbt774). To characterise the 'fingerprint' of circulating antibodies they screened a phage random-peptide library with purified immunoglobulins from the serum of cancer patients and identified a number of immunoreactive peptide motifs. Reactivity correlated with disease progression and poor clinical prognosis. The anti-peptide antibodies recognise the glucose-regulated protein GRP78 which was also upregulated in metastatic prostate cancer.


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    Nature Biotechnology

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    University of Texas M.D. Anderson Cancer Center

  3. The glucose-regulated proteins: stress induction and clinical applications.

    PubMed Abstract | Publisher Full Text OpenURL