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Targeting fragile X

Ilse Gantois and R Frank Kooy*

Author Affiliations

Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium

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Genome Biology 2002, 3:reviews1014-reviews1014.5  doi:10.1186/gb-2002-3-5-reviews1014

Published: 25 April 2002


Ten years after the identification of the gene responsible for fragile X syndrome, recent studies have revealed a list of mRNAs bound by the fragile X gene product and have identified specific sequences required for the interaction between the fragile X protein and its targets. These results are a breakthrough in understanding why absence of the fragile X protein leads to mental retardation.