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The diversity of acetylated proteins

Bogdan Polevoda and Fred Sherman*

Author Affiliations

Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA

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Genome Biology 2002, 3:reviews0006-reviews0006.6  doi:10.1186/gb-2002-3-5-reviews0006

Published: 30 April 2002


Acetylation of proteins, either on various amino-terminal residues or on the ε-amino group of lysine residues, is catalyzed by a wide range of acetyltransferases. Amino-terminal acetylation occurs on the bulk of eukaryotic proteins and on regulatory peptides, whereas lysine acetylation occurs at different positions on a variety of proteins, including histones, transcription factors, nuclear import factors, and α-tubulin.