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Screening the fruitfly immune system

Marc S Dionne and David S Schneider*

Author Affiliations

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5124, USA

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Genome Biology 2002, 3:reviews1010-reviews1010.2  doi:10.1186/gb-2002-3-4-reviews1010

Published: 27 March 2002


The anti-microbial defense system of Drosophila shows functional similarities with the vertebrate innate immune system. Two recent gene-expression profiling studies of fruitflies challenged with infectious agents have identified key molecular players in the fruitfly's response to bacterial and fungal infection, as well as a large number of immune-regulated genes with unknown immunological function.