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Epigenetic reprogramming in the mammalian embryo: struggle of the clones

Mellissa RW Mann and Marisa S Bartolomei*

Author Affiliations

Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA

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Genome Biology 2002, 3:reviews1003-reviews1003.4  doi:10.1186/gb-2002-3-2-reviews1003

Published: 29 January 2002


During preimplantation development in mammals, distinct epigenetic marks on oocyte and sperm DNA are remodeled to an embryonic pattern. A recent study examining global methylation of repetitive elements in various mammals showed that the reprogramming that occurs during normal preimplantation development is aberrant in cloned embryos.