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The past, present and future of genome-wide re-annotation

Christos A Ouzounis1 and Peter D Karp2*

Author Affiliations

1 Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK

2 Bioinformatics Research Group, AI Center, SRI International, Menlo Park, CA 94025, USA

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Genome Biology 2002, 3:comment2001-comment2001.6  doi:10.1186/gb-2002-3-2-comment2001

Published: 31 January 2002


Annotation, the process by which structural or functional information is inferred for genes or proteins, is crucial for obtaining value from genome sequences. We define the process of annotating a previously annotated genome sequence as 're-annotation', and examine the strengths and weaknesses of current manual and automatic genome-wide re-annotation approaches.