Genome Biology
Volume 3
Issue 2 |
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OpinionThe past, present and future of genome-wide re-annotationChristos A Ouzounis1  and Peter D Karp2  1Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK 2Bioinformatics Research Group, AI Center, SRI International, Menlo Park, CA 94025, USA  author email corresponding author email
Genome Biology 2002,
3:comment2001.1-2001.6doi:10.1186/gb-2002-3-2-comment2001
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31 January 2002 |
Subject areas: Bioinformatics, Genome studies, Biochemistry and structural biology Abstract
Annotation, the process by which structural or functional information is inferred for genes or proteins, is crucial for obtaining value from genome sequences. We define the process of annotating a previously annotated genome sequence as 're-annotation', and examine the strengths and weaknesses of current manual and automatic genome-wide re-annotation approaches. | 
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