An overview of the synteny between mouse and human is shown in Apollo's synteny display. The central (larger) chromosomes are the human chromosomes, which are flanked by their syntenic mouse chromosomes. Apollo clusters DNA-DNA matches into syntenic regions, eliminating any short paralogous DNA-DNA hits. Selecting a segment displays a menu showing the chromosomal coordinates of the match in the genome sequence of both organisms and offering the user two options. The first opens a gene-level synteny view, illustrated in Figure 9. The second option reads the raw DNA-DNA matches that were used to produce the synteny and displays a sequence-level view of the similarities between the two genomes.
Lewis et al. Genome Biology 2002 3:research0082.1-0082.14 doi:10.1186/gb-2002-3-12-research0082