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Variations in abundance: genome-wide responses to genetic variation... and vice versa

Bruce A Hamilton

Author Affiliations

Department of Medicine (Division of Genetics), Department of Cellular and Molecular Medicine, and Rebecca and John Moores UCSD Cancer Center, University of California San Diego School of Medicine, La Jolla, CA 92093-0644, USA

Genome Biology 2002, 3:reviews1029-reviews1029.3  doi:10.1186/gb-2002-3-10-reviews1029

Published: 19 September 2002


How do naturally occurring polymorphisms in DNA sequence relate to variation in gene expression? Recent work to map genetic sources of expression variation has shown a surprising balance between cis and trans effects. Other work suggests some chromosomal clustering of genes by expression pattern. A synthesis of approaches may provide new insight in to adaptive mechanisms in evolution and the population basis of complex traits.