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Autosome inactivation by ectopic XIST in differentiated cells

Cathy Holding

Genome Biology 2002, 3:reports0053  doi:10.1186/gb-2002-3-10-reports0053

Published: 30 September 2002


Human XIST, when integrated into autosomes in a fully differentiated adult human tumor cell line, caused localized chromosome inactivation, counter to all previous concepts of a specific narrow window of opportunity for X-inactivation