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The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis

Andrew J Furley

Author Affiliations

Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK

Genome Biology 2001, 2:reviews1026-reviews1026.5  doi:10.1186/gb-2001-2-9-reviews1026

Published: 29 August 2001


A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap approach targets the genes involved in brain wiring and labels the axons of neurons expressing those genes, enabling the effects of mutations to be observed directly.