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The genome of Mycobacterium leprae: a minimal mycobacterial gene set

Varalakshmi D Vissa* and Patrick J Brennan

Author Affiliations

Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA

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Genome Biology 2001, 2:reviews1023-reviews1023.8  doi:10.1186/gb-2001-2-8-reviews1023

Published: 3 August 2001


Comparison of the recently sequenced genome of the leprosy-causing pathogen Mycobacterium leprae with other mycobacterial genomes reveals a drastic gene reduction and decay in M. leprae affecting many metabolic areas, exemplified by the retention of a minimal set of genes required for cell-wall biosynthesis.