Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Open Badges Research news


Jonathan B Weitzman

Genome Biology 2001, 2:spotlight-20010718-01  doi:10.1186/gb-spotlight-20010718-01

The electronic version of this article is the complete one and can be found online at:

Published:18 July 2001

© 2001 BioMed Central Ltd

Research news

Mutations in the human BRCA2 gene are associated with susceptibility to early-onset breast cancer, but it is unclear how the wild-type BRCA2 protein works. In the July 17 Proceedings of the National Academy of Sciences, Xia et al. describe investigation of the role of BRCA2 in DNA repair (Proc Natl Acad Sci USA 2001, 98:8644-8649). They expressed BRCA2 in Capan-1 carcinoma cells, the only human cell line that has non-functional BRCA2. BRCA2 expression increased homologous recombination ten-fold, and required interaction with the Rad51 protein. This homologous recombination increase resulted in increased resistance to ionizing radiation. BRCA2 expression had no effect on non-homologous end joining (NHEJ), another double-strand-break repair pathway. Thus, BRCA2 regulation of homologous recombination ensures the repair of damaged DNA to maintain genome integrity.


  1. Breast cancer genetics: what we know and what we need

    PubMed Abstract | Publisher Full Text OpenURL

  2. [] webcite

    Proceedings of the National Academy of Sciences

  3. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.

    PubMed Abstract OpenURL