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Highly Accessed Open Badges Review

A tale of histone modifications

Patrick A Grant

Author Affiliations

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Jefferson Park Avenue, Charlottesville, VA 22908, USA

Genome Biology 2001, 2:reviews0003-reviews0003.6  doi:10.1186/gb-2001-2-4-reviews0003

Published: 5 April 2001


The modification of chromatin structure is important for a number of nuclear functions, exemplified by the regulation of transcription. This review discusses recent studies of covalent histone modifications and the enzymatic machines that generate them.