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Collecting splice variants

Steven G Gray

Genome Biology 2001, 2:reports2014  doi:10.1186/gb-2001-2-10-reports2014

The electronic version of this article is the complete one and can be found online at:

Received:10 August 2001
Published:14 September 2001

© 2001 BioMed Central Ltd


The Human Alternative Splicing DataBase (HASDB) contains information about many of the alternative splicing events that have so far been identified in humans. It has recently been estimated that 42% of human genes may have alternative splicing, indicating that the proteome may be a lot bigger than the genome. From approximately two million mRNA and expressed sequence tag (EST) sequences, 6,201 alternative splices have been identified and entered into this searchable database.


The first stop on the website is a search engine. The user is asked to define his or her search from eight different settings (for example, gene, marker_id and so on). Once the search result is returned, you are presented with a table of links, including external links to indicators of gene and chromosomal locations (such as Genecards, Genatlas, OMIM and Genemap) as well as splicing information. Some sections will slow you down, especially if you are bringing up all the possible splice variants for a gene.

Reporter's comments

Best feature

The search engine is very simple and easy to use and the results are also easily understandable.

Worst feature

To get to the sequence of interest and find an alternative splice in my favorite gene I had to go through multiple series of links, which is tedious. A more direct link would be useful.

Wish list

A graphical image of the splice would improve the site for the casual user.

Table of links

Assumptions made about all sites unless otherwise specified:
The site is free, in English and no registration is required. It is relatively quick to download, can be navigated by an 'intermediate' user, and no problems with connection were found. The site does not stipulate that any particular browser be used and no special software/plug-ins are required to view the site. There are relatively few gratuitous images and each page has its own URL, allowing it to be bookmarked.