Genome sequences and great expectations
1 Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge, CB10 1SD, UK
2 Biological Structures and BioComputing Programme, EMBL, Meyerhofstrasse 1, Heidelberg, Germany
3 Department of Computational Biology and Chemistry, IRBM, Via Pontina, Pomezia, Rome, Italy
4 Protein Design Group, National Center for Biotechnology, Cantoblanco, Madrid, Spain
5 MIT Center for Genome Research, One Kendall Square, Cambridge, MA 02139, USA
Genome Biology 2000, 2:interactions0001-interactions0001.3 doi:10.1186/gb-2000-2-1-interactions0001Published: 29 December 2000
To assess how automatic function assignment will contribute to genome annotation in the next five years, we have performed an analysis of 31 available genome sequences. An emerging pattern is that function can be predicted for almost two-thirds of the 73,500 genes that were analyzed. Despite progress in computational biology, there will always be a great need for large-scale experimental determination of protein function.