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Genome sequences and great expectations

Ioannis Iliopoulos1, Sophia Tsoka1, Miguel A Andrade2, Paul Janssen1, Benjamin Audit1, Anna Tramontano3, Alfonso Valencia4, Christophe Leroy5, Chris Sander5 and Christos A Ouzounis1*

Author Affiliations

1 Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge, CB10 1SD, UK

2 Biological Structures and BioComputing Programme, EMBL, Meyerhofstrasse 1, Heidelberg, Germany

3 Department of Computational Biology and Chemistry, IRBM, Via Pontina, Pomezia, Rome, Italy

4 Protein Design Group, National Center for Biotechnology, Cantoblanco, Madrid, Spain

5 MIT Center for Genome Research, One Kendall Square, Cambridge, MA 02139, USA

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Genome Biology 2000, 2:interactions0001-interactions0001.3  doi:10.1186/gb-2000-2-1-interactions0001

Published: 29 December 2000


To assess how automatic function assignment will contribute to genome annotation in the next five years, we have performed an analysis of 31 available genome sequences. An emerging pattern is that function can be predicted for almost two-thirds of the 73,500 genes that were analyzed. Despite progress in computational biology, there will always be a great need for large-scale experimental determination of protein function.