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Multiple RNA-protein interactions in Drosophila dosage compensation

Hubert Amrein

Author Affiliations

Department of Genetics, Duke University Medical Center, Research Drive, Durham, NC 27710, USA

Genome Biology 2000, 1:reviews1030-reviews1030.5  doi:10.1186/gb-2000-1-6-reviews1030

Published: 6 December 2000


From worms to humans, recognizing and modifying a specific chromosome is essential for dosage compensation, the mechanism by which equal X-linked gene expression in males and females is achieved. Recent molecular genetic and biochemical studies have provided new insights into how regulatory factors in Drosophila are recruited and assembled on the X chromosome, leading to the essential hypertranscription of its genes.