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Rearranging kinetochores

William Wells

Genome Biology 2000, 1:spotlight-20001116-01  doi:10.1186/gb-spotlight-20001116-01

The electronic version of this article is the complete one and can be found online at:

Published:16 November 2000

© 2000 BioMed Central Ltd

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Rsc is a member of the SWI/SNF family of chromatin-remodeling complexes in yeast. Unlike the main yeast SWI/SNF complex, Rsc is required for progress through mitosis, and absence of Rsc function alters the chromatin structure of yeast centromeres. This could be explained if Rsc was necessary for the transcription of certain mitotic genes, but in the November 21 Proceedings of the National Academy of Sciences, Xue et al. propose that Rsc's effect on centromeres may be direct (Proc. Natl. Acad. Sci. USA 2000, 97:13015-13020). They isolate BAF180, a unique component of the PBAF (Polybromo, BRG1-associated factors) or human Rsc complex. PBAF is localized at kinetochores in prometaphase cells or in the presence of the anti-microtubule drug nocodazole. Thus PBAF/Rsc activity may be needed at kinetochores to create an altered chromatin structure suitable for spindle attachment.


  1. RSC, an essential, abundant chromatin-remodeling complex.

    PubMed Abstract | Publisher Full Text OpenURL

  2. Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex.

    PubMed Abstract OpenURL

  3. A mutation in NPS1/STH1, an essential gene encoding a component of a novel chromatin-remodeling complex RSC, alters the chromatin structure of Saccharomyces cerevisiae centromeres.

    PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

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    Proceedings of the National Academy of Sciences