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Hedgehogs make both fish and fly eyes

William Wells

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Genome Biology 2000, 1:spotlight-20000929-02  doi:10.1186/gb-spotlight-20000929-02

The electronic version of this article is the complete one and can be found online at:

Published:29 September 2000

© 2000 BioMed Central Ltd

Research news

The fly eye is patterned by a morphogenetic wave driven by the Hedgehog signaling protein. In the 22 September Science Neumann and Nuesslein-Volhard report that neuronal differentiation in zebrafish eyes is dependent on a similar wave of hedgehog proteins (Science 2000, 289:2137-2139). Previous work on Pax6 already indicated that the mechanism of eye induction is conserved across the animal kingdom. But variations in eye structure suggested that events downstream of eye induction must have evolved multiple times. The new results suggest that at least some of the downstream events may have evolved only once, before vertebrate and invertebrate lineages diverged.


  1. Growth and differentiation in the Drosophila eye coordinated by hedgehog.

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  2. [] webcite

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  3. Pax 6: mastering eye morphogenesis and eye evolution.

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